![]() from the Florida Institute of Technology, a Master’s in Clinical Investigation from the University of Massachusetts Medical School and a Ph.D. Mueller was honored for holding one of the top 10 patents in Massachusetts by the Boston Patent Law Association for inventing dual function AAV vectors with a silence and replace modality.ĭr. Mueller has been the recipient of many honors and awards for his research, including the Bettina Irvine Family Award for Excellence in Alpha-1 Research, the Alpha-1 Foundation Shillelagh Award, the ALS Angel Fund Angel Award, and the Parker B. A sought after speaker at national and international scientific meetings, Dr. ![]() Currently, he serves as Head of Gene Therapy at Sanofi. Mueller was awarded tenure by the Department of Pediatrics at the University of Massachusetts Medical School in 2018. Mueller was the first to describe a regulatory T-cell response to the AAV capsid in patients, as well as the first to investigate AAV-mediated miRNA silencing in patients. He has worked on translating AAV-mediated gene therapies in alpha-1 antitrypsin deficiency, amyotrophic lateral sclerosis, Hermansky-Pudlak syndrome and Huntington’s disease. He has had a distinguished academic research career, establishing himself as a thought leader in gene therapy and working on novel vector platforms, gene editing approaches, and mechanisms of gene silencing in the liver and CNS, authoring more than 75 publications and 10 patent applications. ![]() Mueller is an expert researcher specializing in gene therapy and animal modeling of rare genetic disorders.
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Trying to migrate a library now just displays an error message saying you need to find a machine with macOS Monterey or earlier to perform the migration. However, with the release of macOS 13 Ventura in 2022, Apple dropped support for this migration process. ![]() PowerPhotos included its own migration assistant that would help with migrating multiple libraries, but still left the process of migrating each library to the Photos app itself. ![]() I released PowerPhotos 2.3 today, which adds a feature that fills a hole for folks who have old iPhoto or Aperture libraries they want to bring over to Photos.Īpple released Photos as a replacement for iPhoto and Aperture back in 2015, and included a “migration” feature that would let people move their old iPhoto or Aperture library to Photos and preserve most of the library data such as album organization, photo metadata, and edits along with the photos themselves. ![]() As of 2015, the latest version of Out of the Park Baseball is OOTP 16, which is the first to feature full licensing from Major League Baseball, so the game can feature real league and team logos for the majors and minors, as well as historical team logos and the World Series trophy. With the purchase of Sports Interactive by SEGA, however, Out of the Park Developments split away on their own again. In 2004, OOTPD partnered with the UK company Sports Interactive Limited and was able to grow the Out of the Park Baseball franchise with Sports Interactive's coding technology and development platform. The first game in the Out of the Park Baseball series was released in May 1999 with the help of Sean Lahman, who sold the game through his website. Visualize the Win: Out Of The Park Baseball 23 features a major graphical overhaul, with enhanced 3D player animations to bring your favorite MLB players from the past and present to life. You cant sign Lindor just like you cant trade for Bellinger. OOTP Developments previously published Inside the Park Baseball and Title Bout Championship Boxing, which is now owned by publisher PISD. From long-requested features such as the all-new 3D Ballpark Construction Kit to a completely overhauled scouting system, improved 3D animations, real 2020 teams & rules for MLB and a dozen international pro baseball leagues, plus a completely refreshed Perfect Team online multiplayer mode, OOTP 21 has more than something for every kind of player. Because I traded for so many young SPs, I put up the leagues best in all pitching categories while paying next to nothing. The player takes on the baseball captain, who has to lead. If strategy and numbers get your heart racing, then this game. MLB 9 Innings 16 is a Sports, Single-player, and Multiplayer video game offered by Com2uS Corporation. A new game called Beyond the Sideline Football is in development. Out Of The Park Baseball 17- 92 Not for the action minded, OOTP is more of a thinking mans game. I guess we know now, for certain, that they were selling a game with content that was not legal. OOTP Developments also publishes Franchise Hockey Manager and MLB Manager (formerly iOOTP Baseball). I was an EARLY supporter of OOTP, and have been a member of their forums since 2002. It isnt a photorealistic, graphics-heavy game like PlayStation 4s (799.95 at Amazon) MLB 15 The Show (46. The company has created several new franchises since its inception, starting with the popular and long-running Out of the Park Baseball. OOTP 16 is a simulation and management game designed for baseball statistics junkies. Visualize the Win: OOTP 23 features a major graphical overhaul, with enhanced 3D player animations to bring your favorite MLB players from the past and present to life (including the all-new Cleveland Guardians), adding even more depth to the beloved team MLB management game with a fun and exciting new visual experience. KG is a German game development company co-founded by Markus Heinsohn and Andreas Raht in 1999. Many other simulation-based sports titles that I’ve reviewed over the past couple years struggle to deliver a user experience that provides an experience that I would consider approachable and manageable while still offering depth and realism.Out of the Park Developments GmbH & Co. Additionally, this is not just an issue with Out of the Park Baseball. I understand it’s a text-based game, so there’s going to be navigation issues for newcomers - just as there are periods of learning when you pick up a controller-based game for the first time. However, I still have concerns about accessibility for newcomers. AccessibilityĪs a veteran of the series, it’s easier to navigate around OOTP ’22, and that’s appreciated. Bottom Line The visually upgraded 3-D stadiums and the streamlined user interface are the best improvements in OOTP ’22. So for those who are like me, you may have the same moments of frustration. OOTP ’22 Is a wonderfully deep baseball simulation with a deep learning curve, and so it’s an eternal quest to keep that same depth without scaring anyone away. New features in OOTP 13 included: 2012 major league rosters. The level of frustration for me is enhanced because I love playing controller-based baseball video games to control the action myself. Starting with OOTP 16, the game has licenses for Major League Baseball and Minor League. Regardless of the type of infield shifts I used, there were times where I watched my shortstop hesitate to make a play, or he would simply hold on to the ball when there was obviously enough time to throw the ball to the designated bag for the out. However, BMI can be an inaccurate measure of healthy weight for pregnant women, children, older people, athletes or very muscular people. A BMI of 20-25 is considered healthy for most adults. ![]() ![]() Why is this important?īeing a healthy weight means not being under or overweight. BMI is a widely used measure to find out whether you’re a healthy weight for your height. Use this simple tool to calculate your body mass index (BMI). It is not a diagnostic tool and should not be relied on as a substitute for professional medical or other professional health advice. This calculator has been reviewed by Bupa health professionals and is based on reputable sources of medical research. If your BMI is above or below the normal range but you consider yourself to be of normal and healthy weight for your height, chat with your doctor about any potential health concerns. Height: You have entered a number outside the available range 91cm - 250cm / 3ft 0in- 8ft 2in.īMI is calculated by dividing your weight in kilograms by your height in metres squared.Įnter your measurements and click ‘calculate’ for your body mass index. Weight: You have entered a number outside the available range 30kg - 250kg / 66.15lb - 551.25lb. *According to the National Health and Medical Research Council, a healthy BMI is between 20-25 for most adults. ![]() Talk to your doctor about your BMI and discuss an appropriate and healthy weight for you. This puts your health at risk and is of increasing concern, particularly as you get older. If you are at all concerned or have any health problems, check with your doctor before you start any new exercise programs or eating plans. You might like to talk to your doctor about whether you need to set yourself a new target for a healthy weight. Your weight appears to be a bit above the ideal range. Being a healthy weight has important benefits as it can help reduce your risk of heart disease, diabetes and a range of other conditions. Your BMI is currently within what is considered a healthy weight range. If you do feel you need to put on some weight, it is still important to eat a healthy diet. Unless you’re naturally very slim, you may need to consider ways of gaining weight to bring your BMI to between 20 and 25. You may weigh less than you ideally should. They can help you think of small, practical changes you feel comfortable with to achieve a healthy weight. ![]() See your doctor or health professional and discuss whether you may need to aim at gaining weight. Your weight is less than it ideally should be. Understanding your results and recommended next steps. Get a better understanding of being a healthy weight with our articles on weight management. Skip to content Skip to footer Bupa Healthlink Health conditions Allergies Angina Asthma Cancer & malignancy Cold, flu & cough Cold sore & oral herpes COPD Dementia Diabetes Disability Gastro Gut health Heart attack Knee pain Pain Palliative care STIs Stroke More conditions - Healthy recipes Breakfast Lunch Dinner Dessert Snacks & Drinks Family & pregnancy Getting pregnant Pregnancy Babies Kids Teenagers Families Healthy ageing Postnatal depression Pregnancy loss Mental health & wellbeing Anxiety disorder Body image Depression Grief & loss Mental health Mental illness Selfcare Sleep Health & fitness Diet & nutrition Exercises & workouts Fitness goals Rehabilitation Sports injuries Weight loss & management Sex & relationships Women's health Men's health LGBTQIA+ health Sexual pleasure Relationship advice Safe sex Home Travel & Beauty Healthy homes Pets Skincare Travel tips Health Tools BMI calculator Ideal weight calculator Waist to hip ratio Calorie converter Target heart rate Calories burned calculator Hopefully this will live up to that dream. I found this online somewhere and it helped me get the 25 dungeons trophy. Because at this rate of improvement, Reality Pump could be snapping at the heels of the big RPG developers next time." Bickham said. Two Worlds II Map with dungeon locations Map with dungeon locations By 83nn0 Decemin Two Worlds II Share Followers 1 1 2 Next of 2 83nn0 Members 66 Posted DecemClick here. "I sincerely hope it does well enough to fund a bigger-budget sequel. Most Consecutive Two-Block Gap Jumps In Minecraft (Xbox 360) Anthony. Eurogamer contributor Al Bickham said "Reality Pump clearly knows what makes an RPG tick" in his Two Worlds 2 review and wished for a triple-A sequel to sort out the series' rough edges. Go to the saves folder, a list of folders of saved Minecraft worlds will appear. We rather liked Two Worlds 2 back in the day. You can find out more about Call of the Tenebrae on the game's official site. The new update will also celebrate the game's arrival on Linux / SteamOS. The main multiplayer component is the Adventure mode seven unique maps for up to eight players to accomplish given objectives cooperatively. Reality Pump boasted that its new engine update "allows for a much higher level of character and landscape detail, an HD-GUI, in addition to tons of in-game achievements, co-op multiplayer, and lots of new in-game features and upgrades." It will focus on the Hero's return to Antaloor where he must face an invasion of rat-like creatures called The Chosen. A new mutliplayer game mode, including five brand new maps, is now available on. The first story DLC, Call of the Tenebrae, will arrive toward the end of Q2 2016. special gift for all players of Two Worlds 2. ![]() ![]() There are twenty glyphs in all, and weve mapped. Despite being released over five years ago, the developer is giving its open-world RPG a major push with an all new engine update and story DLC.Īctually, it's getting two story expansions - Call of the Tenebrae and Shattered embrace - along with eight new multiplayer maps. Search the games many maps and, with a keen eye, youll spot a variety of hidden glyphs printed on building walls and out-of-the-way surfaces. For instance, Datamarine's Chartlink II 7000A (2,695). In the meantime, Reality Pump hasn't given up on Two Worlds 2. Some companies are now offering the best of both worlds: an 8' unit that accepts an outside monitor. The developer said it's in the concept stage and scheduled for development over the next three years. This guide to Two Worlds II contains a detailed description of all the quests available in the game, together with all the possible solutions, endings and their consequences. Two Worlds 3 is officially happening, series developer Reality Pump Studios has announced. ![]() Typical gauge sizes and microns equivalent are It is related to the SI measurement of microns as 1 micron = 4 gauge. What does Mil / Gauge mean when describing a Sleeve Mil/Gauge is the measurement of thickness of plastic Outers & Inner Sleeves. The polypropylene Outer is very smooth and soft but also not as soft as the poly Outers This is because polypropylene is a harder material than polyethylene. Polylypropylene Provides cost-effective Long-Term Archival safe protection for all of you records - Acid Free, Crystal Clear Glass Like Material & 100% Transparent. LP Outer sleeves using a Hybrid mix of 2.5mil 250 Gauge Polypropylener & Polyester Film and die-cut to exactly 12.75 x 12.75 inchesĬrystal Clear with Glass like Brillance and High strengthĪcid Free & Archival for long term storageĪnti-Static & are ideal to highlight your records, thanks to their very high transparency and Glass like brilliance. Select Qty Break Prices & Supplied in 50, 100 Packs ![]() ( PACK SIZE 50 ) Scroll to bottom of page to order Qtys required ![]() For example, the Brawny and Thick-Skinned traits are excellent for Swordsmen because they can be built as tanks. These trait selections were picked according to the strengths of each class.
![]() The Z-Vibe is also recommended for hypersensitive individuals.For sensory-seekers who crave oral stimulation, massaging the gums with the Soft Brush Tip can be particularly helpful.ĭecrease Oral Sensitivities and Food/Texture Aversions: Its gentle vibration can help increase oral awareness and provide much needed proprioceptive input to the lips, cheeks, tongue, and jaw. The Z-Vibe is highly recommended for individuals with hyposensitivities and low oral tone.Some people simply do not like vibration - and that's ok! Even without vibration, the Z-Vibe® can still provide a vast range of sensory stimulation. Please note that by no means does an individual have to use vibration to acquire skills for feeding and articulation. Its gentle vibration provides a new level of tactile awareness for additional sensory feedback, to help "wake up" the mouth, and to draw more acute attention to specific movements of the cheek, jaw, lips, and tongue. doesn’t provide enough input, simply turn the Z-Vibe® on. When just touching the lips, tongue, cheeks, etc. You can also follow up by prompting the individual to say the tongue tip sounds /t/d/n/l/. Then remove the Z-Vibe® and instruct the individual to touch the same spot with his/her tongue tip. For example, use the Z-Vibe® to apply gentle pressure to the alveolar ridge (just behind the upper front teeth). Therapists (and trained caregivers) can use it to provide targeted tactile cues within the oral cavity to teach tongue elevation, tongue lateralization, lip closure, rotary chewing, and much more. ARK's Z-Vibe® is an ideal tool to help you do so. But when these two senses are not enough, you may need to physically direct the articulators for certain speech and feeding skills. Most of us are either visual or auditory learners. It contains small parts (including a battery) that may pose a choking hazard: direct adult supervision is required at all times. It is a therapeutic tool intended to be used by a professional therapist (or by parents trained by their therapist). The aluminum option has slightly more weight to it, and the metal is cool to the touch.Ĭaution: the Z-Vibe is NOT a toy. The plastic options are sturdy, affordable, easy-to-clean, and colorfully kid-friendly. The Z-Vibe is available in two different versions: plastic (all of the color options) or metal (aluminum).Recommended for individuals of all ages and abilities under the guidance of a therapist or a trained caregiver.Measures approximately 6.5" in length and less than half of an inch in diameter.Battery included (please note: this is a special Vibe Battery not sold in stores - we recommend buying a spare).Or, you can add an extra one at a discounted price (regularly $5.99) via the pull-down menu above. The Z-Vibe® is sold here with 1 Probe Tip and 1 Switch Tip, other tips sold separately.NO lead, phthalates, PVC, BPA, or latex.Made in the USA, medical grade, FDA compliant.From spoons to toothbrushes to pencils and more, the same handle can shift goals simply by switching out one tip for another. Use the Probe Tip for oral motor assessment and development. To turn the unit on, simply twist the Switch Tip at the opposite end of the handle just until the unit starts to vibrate (please do not over-tighten).ĭesigned with versatility in mind, there are over 35 tip attachments available in various sizes, textures, and resiliencies. The handle comes with a blue Probe Tip on one end and a Switch Tip on the other. This texture can also be brushed along the cheeks, arms, hands, etc. The Z-Vibe®'s sleek, innovative design features a lightweight, plastic handpiece with gentle bumps around its circumference for a non-slip grip. ![]() ![]() Vibration can also be very calming, soothing, and organizing. Its gentle vibration provides a new level of sensory stimulation to increase oral focus and draw more attention to the lips, tongue, cheeks, and jaw. Use it to provide a varied sensory experience and/or to provide targeted tactile cues within the oral cavity. ARK's Z-Vibe® is a vibratory oral motor tool that can help build oral tone and improve a variety of speech, feeding, and sensory skills. I am beginning to re-cognize what it means to know and this feels affirming, hopeful and exciting! Sometimes it seems like neuroscience is finally proving what teachers and elders have known intuitively forever! I’m curious about combining my experience with concept-based curriculum and instruction with the power of re-storying, timeless and sustainable practices that can help us be in better relationships with the natural world, embodied pedagogies that respect our need to move, and unleashing and nurturing our offerings to the world as unique individuals. Marie Batiste’s articulation of learning spirit resonates with me. These teachings inform my coaching sessions and it’s exciting to see the results. I have so much more to learn and am thankful I have years ahead to keep growing. I also took a course on Indigenous ways of knowing (two of our required readings were Robin Wall Kimmerer’s Braiding Sweetgrass and Dr. My PhD coursework has introduced me to additional forms of inquiry that I had yet to explore as formal research practices such as poetic and embodied inquiry. ![]() I know that retention is important in school environments and teaching during the pandemic has put additional pressures on all aspects of the education system. Many talk about wanting to make (even) bigger impacts within and beyond their classroom but feel unable to do so or unsure how to proceed. A major theme is feeling that they need to convince others why their best practices are good for kids. Sometimes they feel so frustrated, they question whether to stay in education at all. I work primarily supporting visionary educators who strive for joyful, agentic learning for themselves and their students yet are facing many constraints (e.g., budget, time, conflicting philosophies, pandemic-related challenges, etc.). As a consultant to experienced and new teachers, I speak directly, and frankly, with teachers regularly. They share their passion for teaching and struggles with job related stress. What is a professional inquiry you are currently pursuing? We know teachers matter.In fact, teachers are the single most important aspect of schooling.How do we best support ‘agentic’ teachers when they threaten to leave teaching? For example, students design their own contexts for project work and choose when and how to take mastery-based tests. I was fortunate to co-lead workshops and trainings with Trevor right out of university, in my first five years of teaching, which established my drive to serve colleagues through hands-on professional learning. He taught me to hold high standards and make math learning truly relevant to everyday living. He is an experienced principal with a consulting business ( The Power of Ten) and I felt so lucky to learn from him. The other person who comes to mind is my math methods professor: Trevor Calkins who brought a holistic, “math as a teachable moment” approach to his work. She launched a public speaking program, steeped us in cultural arts (e.g., hand painting Ukrainian Easter eggs with real candles) and allowed us to pursue our own inquiries (I decided to follow my interest in hairstyling and color and really did a number on my Barbie doll’s head)! She also led the school’s choir and took us to festivals and competitions. She was incredibly dedicated, very professional and it was clear to us that she absolutely loved her job. Who was the teacher who made the most positive impact on your life?įirst, my Grade 7 homeroom teacher: Mrs. ![]() in Curriculum and Pedagogy with a specialization in cross-faculty inquiry. This is when I really became passionate about cross-faculty inquiry. ![]() The program offered multiple practicum opportunities and required coursework outside of Education. I returned home to fast track my B.Ed degree at the University of Victoria. The pedagogical connections I felt can only be described as ‘magic’. This experience catalyzed my interest in teaching. In 1997, I lived in Beijing and taught English to learners of all ages in three types of settings: with youth in a community center, with adults through City University and with individual business professionals in private lessons. Some of my earliest memories are empathic ones sensing others’ needs and doing something about it. I come from a family of teachers, so I was exposed to the importance of education right from the start. ![]() ACDSee Photo Editor boasts the 64-bit power to actualize the original graphics, polished photography, and compelling art imagery you’ve been envisioning. ACDSee Photo Editor 11 Features: Total Photography ControlĬut straight to the creative part with this dedicated image adjustment and layered editing software. ![]() Easily share your photos and memories to facebook, twitter and email or invite anyone to view your photos and albums. Add text to your photos, or alter photos using a range of special effects including Sheet Metal, Pencil Drawing, and Oil Paint.ĪCDSee Online is the best way to manage, organize, and share all your images safely in the cloud. Blending tools like Clone and Manual Blur enable you to fine-tune details. You can use the Photo Correction Wizard to instantly fix common problems such as light levels, red-eye, and rotation. Rescue photos that are too light or too dark with the Lighting tool, powered by ACDSee’s patented LCE (Lighting and Contrast Enhancement) technology. Quickly modify effects, switch their order, or delete them at any time. Add vector text and shapes over rasterized images. ACDSee Photo Editor 11 also provides comprehensive color management.įurthermore, this photo editor allows you to import and apply Photoshop plug-ins for further creative freedom.ĪCDSee Photo Editor lets you edit and create with the versatility of objects. With GPU-accelerated layers engine and adjustment layers, as well as quality performance for speedy filter application, ACDSee Photo Editor 11 will get you to finished faster.Įnjoy comprehensive support for all of the most popular image formats. Get down to work right away with rapid launching. It allows you to turn any shot into your best shot.Īpply stunning effects and filters, use precision targeting, work with layers, correct flaws, and make advanced pixel-based edits to effortlessly create.ĪCDSee Photo Editor is completely customizable – includes hot keys too! For enhanced workflow efficiency, you can tear off, move, stack, dock, and hide panes and toolbars anywhere you like. ![]() ACDSee Photo Editor 11 is the perfect software for creating amazing digital projects with your photos. |